2-(Tributylstannyl)pyrimidine Property

Boiling point:

381.2±25.0 °C(Predicted)

Density 

1.164 g/mL at 25 °C

refractive index 

n20/D1.512

Flash point:

>110℃

storage temp. 

Sealed in dry,2-8°C

solubility 

soluble in Methanol; Ethyl Acetate; Dichloromethane; Chloroform; DMF; DMSO

form 

liquid

pka

1.42±0.33(Predicted)

color 

Colourless

Safety

Hazard Codes 

Xi,T,N

Risk Statements 

21-25-36/38-48/23/25-50/53

Safety Statements 

36/37/39-45-60-61-35

RIDADR 

UN 2788 6.1 / PGIII

WGK Germany 

3

HazardClass 

IRRITANT, TOXIC, KEEP COLD

HS Code 

29339900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-(Tributylstannyl)pyrimidine Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Uses

2-(Tributylstannyl)pyrimidine is an organotin compound used in Stille coupling reaction. This can be used as one of the precursors in the synthesis of 2-aminopyridine oxazolidinones as potent and selective tankyrase (TNKS) inhibitors and the synthesis of canagliflozin, a novel inhibitor for sodium-dependent glucose cotransporter.
It can also be used in the preparation of various (2-pyrimidyl)silanes.